The Psychonauts are an elite group of international secret agents born with psychic abilities. Children born with psychic talents are sent to Whispering Rock Psychic Summer Camp, where they are trained to be agents. Truman Zanotto, father to Lili Zanotto, is the grand head of the Psychonauts.
It appears there are laws restricting how Psychonauts can use their powers. If the player tries to use the Psycho-Portal on a camper it fails and the following text is displayed: "In accordance with Section 3, Paragraph 1 of the "Young Minds Protection Act," any device created for the purpose of invasive psychic procedure must have built-in safeguards which make its use upon anyone under the age of eighteen (18) impossible."
- According to Ford Cruller, The motto of the Psychonauts is "Prepare your mind."